Senior Scientist, Antibody Purification

GigaGen seeks a talented, highly motivated Senior Scientist, Antibody Purification. The successful candidate will support the expression and purification of antibodies and antibody derivatives for early in vitro and in vivo efficacy studies. This will include extensive lab work to develop protocols for the expression and purification of novel formats, as well as planning and management of routine projects. This position will initially work closely with current scientists and techs, with the expectation of eventually taking over daily management of the protein core and scaling up current processes. This position will report to the VP or Process Development.

Tasks include but are not limited to:

  • Develop protocols for expression and purification of antibodies and antibody derivatives, including antibodies of different isotypes, bispecific antibodies, and antibody fusions
  • Optimize and implement workflows for routine protein expression, purification and documentation
  • Develop and implement protocols for protein characterization
  • Mentor and train junior lab members in routine expression and purification tasks
  • Troubleshoot and improve processes when needed
  • Maintain LC instrumentation and help plan for future expansion
  • Manage protein purification and expression projects, including developing proposals, organizing RAs, and analyzing and presenting data

Qualifications and Skills:

  • PhD in biochemistry, chemical engineering, structural biology or a related field and 2 years of industry experience OR BS/MS with at least 5 years of relevant industry experience
  • Extensive experience with antibody purification is a must, including affinity, polishing, and formulation techniques
  • Experience with FPLC and HPLC operation and troubleshooting
  • Proficiency in protein analytical techniques, including SDS-PAGE, western blot, SEC, ELISA, affinity measurement, and flow cytometry
  • Familiarity with protein expression platforms, expression construct design, and mammalian cell culture
  • Interest in project management is required, prior experience is a plus
  • Able to communicate with a variety of individuals and deliver results in a timely fashion

GigaGen is an equal opportunity employer. All applicants will be considered for employment without attention to race, color, religion, sex, sexual orientation, gender identity, national origin, veteran or disability status.