GigaGen to Present on Copying and Mining Immune Systems for Drug Discovery at the LakePharma Protein Engineering Symposium

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GigaGen Inc., a biopharmaceutical company with patented technology for discovery of T cell receptor (TCR) and antibody drugs from human and mouse immune repertoires, today announced that Dave Johnson, Ph.D., CEO of GigaGen, will present a research and development update at the 2016 LakePharma Protein Engineering Symposium at the South San Francisco Conference Center in California. The presentation titled “Copying and Mining Complete Immune Systems” will take place at 9:00am Pacific time, on Friday, October 7, 2016.

Read the full press release.

 

 

GigaGen and Cellular Therapeutics Ltd Sign Collaboration for Novel TCR Discovery Directly from Patient’s T cells

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GigaGen Inc., a biotechnology company with patented technology for discovery of T cell receptor (TCR) and antibody therapeutics from human immune repertoires, today announced a collaboration with Cellular Therapeutics Limited (CTL) to investigate TCR sequences in Tumor Infiltrating Lymphocytes (TIL) for therapeutic potential. CTL, based in Manchester, England, is an immuno-oncology company specializing in the use of autologous TIL to fight a range of cancers.

Read the full press release.

GigaGen Wins Best E-Poster Award at ESID for Presentation of Preclinical Data for Recombinant Intravenous Immunoglobulin (IVIG)

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GigaGen’s CEO, Dave Johnson, PhD, won the Best E-Poster Award for his presentation on “Manufacturing and Preclinical Validation of Recombinant Intravenous Immunoglobulin for Primary Immunodeficiency” in the Immunoglobulin and Immunomodulatory Therapy session on September 23, 2016 at the 17th biennial meeting of the European Society for Immunodeficiencies (“ESID”) in Barcelona, Spain.

For details of the presentation read the full press release.

GigaGen Announces $1.5M NIH Grant Award for Development of Recombinant Intravenous Immunoglobulin

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GigaGen Inc., the leading innovator in massively high-throughput immune repertoire single-cell sequencing and protein expression, today announced that it has been awarded a $1.5 million Phase II grant from the National Institutes of Health (NIH). The Phase II grant was awarded through the NIH Small Business Innovation Research (SBIR) program in from the National Institute of Allergy and Infectious Diseases (NIAID). The grant supports development of natural repertoire recombinant intravenous immunoglobulin (rIVIG) “hyperimmunes” against common pathogens for patients with primary immune deficiency (PID).

Read the full press release.

GigaGen Announces Issue of US Patent for Polyclonal Antibody Production

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GigaGen Inc., the leading innovator in massively high-throughput immune repertoire single-cell sequencing and protein expression, today announces that the United States Patent and Trademark Office has issued U.S. Patent No. 9,422,547, covering protein expression methods for the production of polyclonal antibodies from natural immune repertoires. GigaGen has exclusive rights to the patented technology and is leveraging the invention to develop recombinant intravenous immunoglobulin (rIVIG).

Read the full press release.

GigaGen Highlighted in Biospace.com Story

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GigaGen’s development of the world’s first synthetic immune system was covered recently in the Biospace.com story Bay Area’s GigaGen Develops Synthetic Immune System to Harness Antibodies.

 

According to the article, “The development of therapeutics that harness the body’s immune system has exploded in popularity among biotech companies with many investing heavily in research and development. Now, GigaGen, a biotech startup with its roots at Stanford University, has developed one of the world’s first synthetic immune system that executives believe will allow the company to treat multiple illnesses and develop drugs at a much faster pace.”

GigaGen Announces Successful Completion of Technical Goals on Four NIH Grant Projects

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GigaGen Inc., a world leader in massively high-throughput immune repertoire single-cell sequencing and protein expression, today announced that it has achieved all of the technical goals for four Phase I grants from the National Institutes of Health (NIH). The Phase I grants were awarded through the NIH Small Business Innovation Research (SBIR) program in 2015 from the National Cancer Institute (NCI) and the National Institute of Allergy and Infectious Diseases (NIAID). The NIH SBIR program is highly competitive, with <15% of applications receiving funding in most years.

 

Read the full press release.

GigaGen Highlighted in Genome Web

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The potential of GigaGen’s single cell sequencing and expression platform to revolutionize immunotherapy drug development and target discovery was highlighted in the recent Genome Web story Expanding Single-Cell Technology, GigaGen Moves Forward in Drug Development Market.

 

According to the article:

 

“Single-cell analysis firm GigaGen has made a sharp turn in its business plans over the last several years from early intentions in the genomic diagnostics instrument space to now seeking to establish itself in drug development and target discovery.

 

The company’s CEO and Co-founder, David Johnson, spoke with GenomeWeb last week about the firm’s turnabout in focus and the progress it has made over the past several years in adapting its platform to support collaborations with large pharmaceutical companies, as well as its own internal target discovery and drug development efforts based on immune repertoire sequencing enabled by its droplet-based single cell microfluidic technology.

 

Early in its inception, Johnson said, GigaGen was aiming to advance its platform as a tool for sequencing immune cells to monitor and diagnose disease. But, he said, the company realized that ‘even though we had some interesting clinical directions for that, it just wasn’t going to be worth developing in that way … It’s too hard to get diagnostics paid for,’ he said.

 

Shifting focus, the firm began to develop primer sets built around applications that customers or partners would pay for, he said, zeroing in on the use of immune repertoire sequencing — an analysis of the genomic diversity of T- and B-cells in a patient’s overall immune system — as a tool for discovery of novel drug compounds that act on known targets, or for uncovering new targets to support the development of whole new classes of molecularly targeted therapies. An important step for the company in this shift, Johnson said, was the expansion of its platform from a focus on single-cell sequencing, to a system that now takes the genomic data from that immune repertoire sequencing and uses it to create a synthetic system of matched protein expression.”

 

Read the full genome web story.